There is a reason why patients coming up against MTHFR for the first time will probably hear about Deplin. It’s classified as a “medical food” by the FDA and approved for use by people with suboptimal L-methylfolate levels. Now, for most people, the dosage of methylfolate found in Deplin (7.5 or 15mg strength) will be way too high, even for people with multiple MTHFR gene mutations. But this prescription dosage exists because it is often prescribed for patients suffering from… Read more »

I was speaking with someone the other day about type 3 diabetes, which I had never heard of before. “Well,” she said, “it’s Alzheimer’s disease.” Knowing that Alzheimer’s is related to MTHFR gene mutations, this got me thinking about types 1 and 2 diabetes and whether MTHFR is a cause. As with many of the MTHFR-associated illnesses, this gets a little complicated. While MTHFR gene mutations do not directly cause diabetes, hypomethylation and elevated homocysteine (which can be caused by… Read more »