Thyroid problems are becoming increasingly more common in the population. In the United States alone approximately one in 13 people (7.35% or 20 million people) has some kind of dysfunction in their thyroid glands. And those are just the diagnosed cases. The number could be as high as 33 million people. In the vast majority of cases these are being caused by an underlying autoimmune disorder. And now that we know the statistics and connection between MTHFR and thyroid disorders, some of this is starting to make a little more sense.

thyroid butterfly

Someone was disputing Dr. Ben Lynch’s assertion that 50% of people could be affected by MTHFR in a discussion forum the other day, so I thought I’d pull the population frequency data for anyone else who is doubtful. Here it is for MTHFR 677CT and 1298AC. Many of us are affected by MTHFR and just because some doctors aren’t ready to acknowledge it, doesn’t mean that these problems are going away (or that we are). I find it very unsettling that so many scientific people are so quick to refuse to acknowledge that they simply don’t know something. When presented with a possibility in science and medicine, isn’t the prudent thing to accept that perhaps we need more information? I’m leading with this bit of a ramble because I see similarities in the frustrations that both thyroid and MTHFR patients have to deal with.

I am one of these patients. I am compound heterozygous for MTHFR mutations and I was also born with part of my thyroid missing. We are yet to confirm whether the root cause was MTHFR or something else (I lean towards the something else) but as I delve deeper into my knowledge of my own personal health issues it has been enlightening to begin to put together pieces of the puzzle after being in the dark for so long. I do not have Hashimoto’s disease, which is probably the most common autoimmune condition that renders people hypothyroid. Mine was simply a gland malformation issue. But I am hypothyroid nonetheless and like many sufferers of thyroid problems I was under-medicated and improperly treated for my condition for the vast majority of my life.

So how are MTHFR and thyroid problems connected? Dr. Lynch teamed up with the wonderful patient advocate and writer, Mary Shomon recently to explain very simply how the two disorders are connected. I recommend a read of this article even if you don’t have thyroid problems because I think it is one of the clearest explanations of MTHFR that Dr. Lynch has put forth so far for the layman. To summarize, however, he explains that low levels of thyroxine lead to low levels of vitamin B2, which causes a slowing of the MTHFR enzyme and thus low methylfolate levels.

But this does not explain a causal relationship between the two. In fact, I have not seen anything that demonstrates that hypothyroidism is caused by MTHFR gene mutations. As quoted on the website of Dr. Izabella Wentz, author of Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause, a 2013 study found no higher incidence of MTHFR gene mutations in Hashimoto’s patients than in the normal population. Dr. Wentz’s book appears to be an interesting one, which I have not read yet. Her website’s homepage states that “most patients with Hashimoto’s and hypothyroidism will have acid reflux, nutrient deficiencies, anemia, leaky gut, food allergies and adrenal insufficiency.  Symptoms of impaired digestion/absorption, anxiety, chronic fatigue and chemical/environmental allergies may be seen as well.”  Well, this goes right along with my last post on gut issues and the general conclusions that much of my reading on autoimmune disorders and MTHFR-related chronic illness has brought me to. Viruses have also been implicated as potential troublemakers in various thyroid conditions. One study detected the presence of retroviruses and mumps in subacute thyroiditis, retroviruses in Graves’s disease and Human T-lymphotropic virus (HTLV-1), enterovirus, rubella, mumps, herpes (HSV), Epstein-Barr and parvovirus in Hashimoto’s.  Another study looked at HSV and Hashimoto’s. Perhaps MTHFR does have some input into this disease after all as the inability to detox and clear viruses is a related issue here. I think more research needs to be done in this area.

The thyroid gland is responsible for the regulation of the metabolism of every cell in the body. Its function is explained in detail in this presentation. It is a very important part of the endocrine system and hypothyroidism can lead to an increase in homocysteine levels and potentially a greater risk of cardiovascular disease . It can also cause health problems like stress, depression, pain and obesity. Hyperthyroidism is also serious, causing rapid heart rate, tremor, weight loss and even heart failure in some patients.  So if you have problems with your thyroid it is essential to get these diagnosed and treated properly. Unfortunately for many undiagnosed, misdiagnosed and undertreated patients this is not happening. The field of endocrinology has been accused of disregarding scientific facts in its assessment of millions of hypothyroid patients. I have experienced this firsthand in my own interactions with many doctors and also anecdotally when speaking with fellow thyroid patients about their experiences.

As much has been written about thyroid problems, I see no need to repeat the facts or proper treatment protocols here. So instead I will leave you with a short list of essential resources to assist you in learning and getting the proper treatment. If you suspect that you are having problems with your thyroid even though your doctor says your labs are “fine” (and I hope you know by now how I feel about that word!), please seek a second opinion from one of the more up-to-date doctors out there. This disease is not usually silent but it is very often ignored.

The National Academy of Hypothyroidism

Stop The Thyroid Madness Thyroid Disease

ThyroidChange doctor list (and other resources) 

Light of Life Foundation (thyroid cancer)

Do you have both MTHFR and a thyroid problem? What have you noticed about your conditions?

14 thoughts on “Things That Plague Us: Thyroid Problems

  1. Angela

    When I said I felt over medicated I meant my thyroid medicine. I have started feeling extremely heat intolerant, waking with that fight or flight feeling, but the worst symptom is high bp came on suddenly.


  2. Wendy

    I would also love to know that: if I “ fix” my mthfr, can I get off thyroid meds? You say you are over medicated— what are your symptoms? How can you tell? I have been told that blood work cannot indicate changes on mthfr-perhaps a reduction in histimine levels, but there is no test that can measure if my folate/cobalim supplementation is working. However I have also started taking serrapeptase enzymes and d-ribose, both of which make a diff in my energy levels.


  3. Angela

    I recently started treatment for mthfr/methylation, I have been hypothyroid for as long as I can remember. After a month or so now feel like I’m over medicated on thyroid medicine. Is it possible/common to need to lower thyroid medication dose? Also would it be possible to not need thyroid medication once my methylation is on track?


    1. Andrea

      Very possible, Angela. Please see your doctor for the latest Free T3, Free T4 and antibodies labs. I’m not sure about completely getting off of medication if you’ve been on it for a long time but certainly something to discuss with your doctor.


  4. Andrea

    This is common. The older you get the more the cumulative effects of poor methylation set in. That’s a very simple answer. Autoimmune conditions can appear any time. And if something has been attacking your thyroid for a long time then you start to see the effects of the hormone levels. Hard to say more without knowing your history and biochemistry



    I am double c677t and my thyroglobulin antibodies came back at 458.8? Should I be concerned do they have a connection?


      1. Maritza

        No but my Reproductive Endocrinologist said that I should not worry about it. I just had a miscarriage and found these two things mthfr and thyroglobulin antibodies high. I never had any sumptoms and had healthy pregnancies before I am still trying to understand why did I miscarriage.


        1. Andrea

          Ugh – REs are often terrible with thyroid. Yes that can cause a miscarriage and you need to find a doctor (not a RE) who can help you…the MTHFR along with the thyroid disease absolutely must be addressed before you get pregnant again and by someone who knows what they are doing. I’m so sorry for your loss.


          1. Maritza

            Thank you for your response and advice. What I still don’t understand is that why I didn’t have problems before with mthfr have two healthy girls and the pregnancy went well. Does the symptoms appear later in life or at a certain age?

    1. Andrea Post author

      They are a midline defect often associated with MTHFR mutations…I don’t know of a connection to thyroid, necessarily.


  6. Wendy

    Well, I am confused. I found out that I am homog c677t.. I already knew I was hypothyroid. So what green leafy vegetables do I eat? raw kale is out because of its chemical impact on thyroid and cooked kale, which is ok for thyroid, is apparently out door mthfr.. So what do I do?????


  7. Ruth Kongaika

    My family doctor said my labs are “fine”. But, thankfully, I have found two doctors that agree there is something “off” about my thyroid function and are willing to go further with it. Since I have both MTHFR and a thyroid problem, I plan to continue until I feel better.


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